Defy Validation

Defy Biotopicals work. And we’ve got the science to back it up.

Defy delivers powerful, natural bioactives that help build and renew the skin. And these ingredients are scientifically proven to be effective. Research shows that the bioactives in Defy help balance enzymes, support the underlying skin matrix, provide antioxidant benefits, and more.

To read the full studies, click the links below:

1. Ho, J. N., et al. Inhibitory Effect of Aucubin Isolated from Eucommia ulmoides against UVG-Induced Matrix Metalloproteinase-1 Production in Human Skin Fibroblasts. Biosci. Biotechnol. Biochem., 69 (11), 2227-2231, 2005. Read more here

1. Srinivasan, M., Sudheer, A. R., Menon, V. P. Ferulic Acid: Therapeutic Potential Through Its Antioxidant Property. J. Clin. Biochem. Nutr., 40 (2), 92-100, March 2007. Read more here.

1. Sang, S. et al. New Unusual Iridoids from the Leaves of Noni (Morinda citrifolia L.) Show Inhibitory Effect on Ultraviolet B-Induced Transcriptional Activator Protein-1 (AP-1) Activity., Bioorganic & Medical Chemistry 11, 2499-2502. 2003. Read more here.

1. Kim, S. W. et al. Induction of Extracellular Matrix Synthesis in Normal Human Fibroblasts by Anthraquinone Isolated from Morinda citrifolia (Noni) Fruit. J Med Food 8 (4), 552-555. 2005. Read more here.

1. Sang, S et al. Citrifolinin A, a new unusual iridoid with inhibition of Activator Protein-1 (AP-1) from the leaves of noni (Morinda citrifolia L.). Tetrahedron Letters 42: 1823–1825, 2001. Read more here.

   *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.